Immune system in our body works as an intelligent ‘security system’, having various mechanism used at apparent time & suitably best to protect our body. One important method is – generating antibodies to destroy the antigens. But in some cases our Immune system malfunctions, it start recognizing some cellular proteins, especially nuclear proteins as antigens, hence generating antibodies against them. This situation results in what is referred to as “autoimmune disease”. In current clinical and diagnostic perspective, un-specific symptoms, slowly developing conditions, need for careful selection among treatment options makes this subject one of the most challenging and important area of modern medicine.